KMID : 1130620120080040301
|
|
Journal of Clinical Neurology 2012 Volume.8 No. 4 p.301 ~ p.304
|
|
Association between the G252A Tumor Necrosis Factor-¥â Gene Polymorphism and Medication-Overuse Headache
|
|
Ishii Masakazu
Onaya Tomomi Katoh Hirotaka Kiuchi Yuji Kasai Hideyo Kawamura Mitsuru Shimizu Shunichi
|
|
Abstract
|
|
|
Background and Purpose: Migraine patients are particularly prone to the complication of medication-overuse headache (MOH). Although it has been shown that A allele carriers for the tumor necrosis factor (TNF)-¥â gene G252A polymorphism are at high risk of the development of migraine without aura, the relationship between the TNF-¥â gene G252A polymorphism and MOH is unknown. We investigated whether the TNF-¥â gene G252A polymorphism is involved in the aggravation of migraine by overuse of medications.
Methods: Forty-seven migraine patients (6 males and 41 females; age 36.4¡¾10.3 years, mean¡¾ SD) and 22 MOH patients (1 male and 21 females; age 39.6¡¾9.9 years) who had migraine were included in this study. The genotype for the TNF-¥â gene G252A polymorphism was determined by polymerase-chain-reaction restriction-fragment-length polymorphism analysis.
Results: The distribution of TNF-¥â gene G252A genotype frequency differed significantly between migraine and MOH patients (p=0.013). The G/G genotype was carried by 23% of the migraine patients but it was absent in MOH patients.
Conclusions: G/G genotype carriers appear to be less susceptible to the aggravation of migraine by overuse of medications. The G252A TNF-¥â gene polymorphism may be one of the factors contributing to the complications of MOH in patients with migraine.
|
|
KEYWORD
|
|
medication overuse headache, migraine, tumor necrosis factor gene
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|